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Can I use XSIBackup on VMWare workstation, attached an external USB 5TB drive formatted as NTFS to the XSIBackup VM and backup my ESXi host VMs to the NTFS drive? If so, how do I go about doing this please. Thanks.
Yes, in the event that you want to experiment with not yet tested scenarios and not very recommendable file systems you could run ©XSIBackup-App in ©VMWare Workstation and attach an NTFS disk, but:
Why would you want to do so when the appliance has been designed to run in ©ESXi and to use XFS or ext 3/4 file systems?